Prof. Dr. Volkmar Gieselmann

The group is interested in lysosomal shingolipid storage diseases which mainly affect myelin. Lipid storage is caused by deficiencies of lysosomal enzymes which are involved in the degradation pathways of these sphingolipids. Disease in the focus of the group are metachromatic leukodystrophy and Krabbe disease. We try to understand how storage of lipids affects function of the myelin producing oligodendrocytes and Schwann cells. The second major interest in the development of therapies for these devastating and so far incurable diseases.