The main focus of my group is on dissecting the relationship between interchromatin space, chromatin and transcription, and how the underlying molecular mechanisms coordinate stress response in age-related processes and neurodegeneration. Our work carries multiple implications ranging from understanding disease etiology to the identification of druggable targets. Our studies comprise mouse models, patient-derived material and state-of-the art (epi)genomics, the latter supported by strong bioinformatics/computational biology core.