Alzheimer’s disease (AD) is the most common form of dementia and characterized at the neuropathological level by the combined occurrence of intraneuronal aggregates of the microtubule associated protein tau and extracellular ß-amyloid plaques. We are interested in molecular and cellular mechanisms involved in the pathogenesis of AD. Our research is focused on the understanding of intra- and intercellular signaling pathways that contribute to Alzheimer-associated neurodegeneration. In particular, we try to dissect the metabolism of the amyloid ß-peptide, its post-translational modifications and aggregation. Another line of research addresses of the role of membrane lipids in the subcellular transport and activity of disease-related proteins. The overarching aim is to provide better insight into the pathogenesis of AD that could help to develop strategies for prevention and therapy, and identify targets for molecular diagnosis and differentiation of this disease.