Medicinal chemistry and molecular pharmacology of purine binding membrane proteins (purine receptors, ectonucleotidases); lipid-activated and orphan G protein-coupled receptors; drug development; inflammatory and neurodegenerative diseases; cancer. Key questions: What are the (patho)physiological roles of the membrane receptors and ectonucleotidases of interest? Can we develop potent and selective drugs addressing those targets? Do these drugs show effects in disease models?