Group Leader, Neurovascular Diseases
German Center for Neurodegenerative Diseases (DZNE)
D- 53127 Bonn
Tel: +49 (0) 228 43302-684
Head, Vascular Neurology
Department of Neurology, University Hospital Bonn
D- 53127 Bonn
Tel: +49 (0) 228 287-15736
Fax: +49 (0) 228 287-15024
Website Petzold Group
Website Department of Neurology
We aim to identify the cellular signaling pathways and mechanisms by which glia, and astrocytes in particular, contribute to disease initiation and progression in neurodegenerative diseases (such as Alzheimer’s disease and vascular dementia) as well as stroke. In addition, we are interested in the contribution of cerebrovascular changes to the pathogenesis of these diseases.
We investigate these questions in models of Alzheimer’s disease, vascular dementia and stroke, using techniques such as in vivo two-photon microscopy, MRI, electropyhsiology, genetic and pharmacological calcium indicators, and behavioral tests. In addition, we seek to translate our experimental findings into clinical studies. To this end, we are involved a number of clinical studies investigating therapeutic strategies and pathogenic mechanisms in stroke and vascular cognitive impairment.
5 most important publications
1. Delekate A, Füchtemeier M, Schumacher T, Ulbrich C, Foddis M, Petzold GC. (2014) Metabotropic P2Y1 receptor signalling mediates astrocytic hyperactivity in vivo in an Alzheimer’s disease mouse model. Nat Commun, 5:5422.
2. Petzold GC, Murthy VN. (2011) Role of astrocytes in neurovascular coupling. Neuron, 71(5): 782-797. Review
3. Petzold GC, Hagiwara A, Murthy VN. (2009) Serotonergic modulation of odor input to the mammalian olfactory bulb. Nat Neurosci, 12(6): 784-791.
4. Petzold GC, Albeanu DF, Sato TF, Murthy VN. (2008) Coupling of neural activity to blood flow in olfactory glomeruli is mediated by astrocytic pathways. Neuron, 58(6): 897-910.
5. Petzold GC, Haack S, von Bohlen Und Halbach O, Priller J, Lehmann TN, Heinemann U, Dirnagl U, Dreier JP. (2008) Nitric oxide modulates spreading depolarization threshold in the human and rodent cortex. Stroke, 39(4): 1292-1299.