Professor Dr. Susanne Schoch-McGovern

Institute of Neuropathology
University of Bonn Medical Center
Sigmund-Freud-Str. 25
D- 53127 Bonn

Phone +49  (0) 228 287-19109
Fax +49  (0) 228 287-19362
susanne.schoch@uni-bonn.de

Website

Curriculum vitae Professor Dr. Susanne Schoch-McGovern

Research Interests

Our research focus are the molecular mechanisms underlying the structural organization of the presynaptic active zone and the molecular alterations involved in physiological and pathophysiological synaptic plasticity. In particular, we are interested in the following questions:

  • What are the fundamental mechanisms underlying the formation and maintenance of the active zone ultrastructure?
  • How does the CAZ contribute to mediating synaptic tenacity and synaptic stability?
  • What are the effects of physiological and pathophysiological activity on the composition and structure of the active zone?
  • Which signal transduction cascades mediate changes in the presynaptic release machinery in response to physiological and pathophysiological activity?
  • Role of the presynaptic release machinery during epileptogenesis.

Techniques

Biochemistry , molecular biology, viral gene transfer, mouse molecular genetics, confocal microscopy, live time-lapse fluorescence imaging of reporter proteins in neuronal cell culture, photoactivation

5 most important publications

1. Alvarez-Baron E, Michel K, Mittelstaedt T, Opitz T, Schmitz F, Beck H, Dietrich D, Becker AJ, Schoch S. (2013) RIM3y and RIM4y regulate neruonal arborization. J Neurosci, 33: 824-839.

2. Pitsch J, Opitz T, Woitecki A, Borm V, Staniek M, Beck H, Becker AJ, Schoch S. (2012) The presynaptic active zone protein RIM1alpha controls epileptogenesis following status epilepticus. J Neurosci, 32:12384-12395.

3. Schoch S*, Mittelstaedt T, Kaeser PS, Padgett D, Feldmann N, Chevaleyre V, Castillo PE, Hammer
RE, Han W, Schmitz F, Lin W, Südhof TC*. (2006) Redundant functions of RIM1a and RIM2a in
Ca2+-triggered neurotransmitter release. EMBO J, 25(24): 5852-5863.*:Corresponding authors

4. Schoch S, Castillo PE, Jo T, Mukherjee K, Geppert M, Wang Y, Schmitz F, Malenka RC, Südhof TC.
(2002) RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active
zone Nature, 415: 321-326.

5. Schoch S, Deak F, Königstorfer A, Mozhayeva M, Sara Y, Südhof TC, Kavalali ET. (2001) SNARE
function analyzed in synaptobrevin/VAMP knockout mice. Science. 294: 1117-1122.