Professor Dr. Christa Müller

Full Professor of Pharmaceutical/Medicinal Chemistry
PharmaCenter Bonn
Pharmaceutical Institute
Pharmaceutical Chemistry I
An der Immenburg 4
D- 53121 Bonn

Phone +49  (0) 228 73-2301
Fax +49  (0) 228 73-2567
christa.mueller@uni-bonn.de

Website

Curriculum vitae Professor Dr. Christa Müller

Research Interests

Medicinal chemistry and molecular pharmacology of purine binding membrane proteins (purine receptors, ectonucleotidases); lipid-activated and orphan G protein-coupled receptors; drug development; inflammatory and neurodegenerative diseases; cancer. Key questions: What are the (patho)physiological roles of the membrane receptors and ectonucleotidases of interest? Can we develop potent and selective drugs addressing those targets? Do these drugs show effects in disease models?

Techniques

Molecular biology, in vitro pharmacology, compound screenning, assay development, chemical synthesis, analytical techniques, analysis of structure-activity relationships.

5 most important publications

1. Flögel U, Burghoff S, van Lent PLEM, Temme S, Galbarz L, Ding Z, El-Tayeb A, Huels S, Bönner F, Borg N, Jacoby C, Müller CE, van den Berg WB, Schrader J. (2012) Selective activation of adenosine A2A receptors on immune cells by a CD73 dependent prodrug suppresses joint inflammation in experimental rheumatoid arthritis. Science Transl Med, 4: 1-8.

2. Fredholm BB, IJzerman AP, Jacobson KA, Linden J, Müller CE. (2001) Nomenclature and classification of Adenosine Receptors An update. Pharmacol Rev, 63: 1-34.

3. Baqi Y, Hausmann R, Rosefort C, Retting J, Schmalzing G, Müller CE. (2011) Discovery of potent competitive antagonists and positive modulators of the P2X2 receptor. J Med Chem, 54: 817-830.

4. Baqi Y, Müller CE. (2010) Synthesis of alkyl- and aryl-amino-substituted anthraquinone derivatives by microwaveassisted copper(0)-catalyzed Ullmann coupling reactions. Nat Protocols, 5: 945-953.

5. Hillmann P, Ko G-Y, Spinrath A, Raulf A, Kügelgen I, Wolff SC, Nicholas RA, Kostenis E, Höltje HD, Müller CE. (2009) Key determinants of nucleotide-activated G protein-coupled P2Y2 receptor function revealed by chemical and pharmacological experiments, mutagenesis and homology modeling. J Med Chem, 52: 2762-2775.