Dr. Gaia Tavosanis

Research group leader
Deutsches Zentrum für Neurodegenerative Erkrankungen e.V.
German Center for Neurodegenerative Diseases (DZNE)
c/o Life & Medical Sciences (LIMES)
Carl-Troll-Str. 31
D- 53115 Bonn

Phone office +49  (0) 228 73-62848
Phone lab +49  (0) 228 73-62837
Fax +49  (0) 228 73-62849
gaia.tavosanis@dzne.de

Website

Curriculum vitae Dr. Gaia Tavosanis

 

Research Interests

Work in our lab addresses:

  1. how functional neuronal circuits assemble during development and
  2. how those circuits can be modified by sensory environment changes during the adult life of the animal?

We use a combination of genetics and in vivo imaging in Drosophila to investigate the molecular regulation underlying neuronal dendrites differentiation and the formation of synaptic contacts within defined circuits. After functional circuits are assembled, we induce controlled changes in the sensory environment of the adult fly or prompt it to form lasting memories. A major focus in the lab is to dissect the structural, synaptic and functional consequences of these manipulations and the molecular cascades that control them.

 Techniques

  • Cell Biological approaches to visualize and manipulate neurons in vivo
  •  Molecular biology (RNA interference, generation of transgenic fly lines)
  • Drosophila genetics
  • Confocal and live cell imaging
  • In vivo imaging
  • Primary neuronal cell cultures
  • Learning and memory behavioural paradigms in Drosophila

 

5 most important publications

1. Sugie A, Hakeda-Suzuki S, Suzuki E, Silies M, Shimozono M, Mohl C, Suzuki T, Tavosanis G. (2015) Molecular Remodeling of the Presynaptic Active Zone of Drosophila Photoreceptors via Activity-Dependent Feedback. Neuron, 86(3): 711-725.

2. Nagel J, Caroline Delandre C, Zhang Y, Förstner F, Moore AW, Tavosanis G. (2012) Fascin controls neuronal class-specific dendrite arbor morphology. Development, 139(16): 2999-3009.

3. Kremer MC, Christiansen F, Leiss F, Paehler M, Knapek S, Forstner F, Kloppenburg P, Sigrist SJ, Tavosanis G. (2010) Structural long-term changes at Mushroom Body input synapses. Current Biology, 20(21): 1938-1944.

4. Leiss F, Groh C, Butcher NJ, Meinertzhagen IA, Tavosanis G. (2009) Synaptic organization of the adult Drosophila mushroom body calyx. J Comp Neurology, 517(6): 808-824.

5. Dimitrova S, Reissaus A, Tavosanis G. (2008) Slit and Robo regulate dendrite branching and elongation of space-filling neurons in Drosophila. Dev Biol, 324(1): 18-30.